Compatibility studies of nateglinide with excipients in immediate release tablets
نویسندگان
چکیده
منابع مشابه
Compatibility studies of nateglinide with excipients in immediate release tablets.
Experiments were done to assess the compatibility of nateglinide with selected excipients in the development of immediate release tablets of nateglinide by thermal and isothermal stress testing (IST) techniques. To evaluate the drug-excipient compatibility, different techniques such as differential scanning calorimetric (DSC) study, infra-red (IR) spectrophotometric study and isothermal stress ...
متن کاملFormulation, development, and optimization of immediate release nateglinide tablets by factorial design.
In the present study, selection of superdisintegrants among sodium starch glycolate, cross povidone, Starch-1500 and cross carmellose sodium (CCS) was carried out for development of immediate release nateglinide tablets (NTG). A 3(2) full factorial design was used to investigate the influence of two independent variables, i.e., amount of selected superdisintegrants and hardness of the tablets, ...
متن کاملRelease Kinetics of Papaverine Hydrochloride from Tablets with Different Excipients
The influence of excipients on the disintegration times of tablets and the release of papaverine hydrochloride (PAP) from tablets were studied. Ten different formulations of tablets with PAP were prepared by direct powder compression. Different binders, disintegrants, fillers, and lubricants were used as excipients. The release of PAP was carried out in the paddle apparatus using 0.1 N HCl as a...
متن کاملIn Vitro Studies of Controlled Release Alfuzosin Matrix Tablets Prepared with Ethylcellulose and Hydroxypropyl Methylcellulose
Extended release formulation of alfuzosin, an a-antagonist used for prostatic hypertrophy, is available in market. It is convenient for older patients to take only one tablet a day. Marketed alfuzosin formulation is three layered geomatrix tablet that requires special facilities, high cost, more time and complex operation than normal direct compression formulation. Therefore, a less compl...
متن کاملPharmacokinetics and Pharmacodynamics of Gliclazide from Immediate and Modified Release Formulation Tablets in Rats
The objective of the study was to compare pharmacokinetic and pharmacodynamic parameters of gliclazide after administration of immediate (IR) and modified release (MR) tablets. The experiment included rats with both normoglyceamia and streptozocin (STZ)-induced hyperglyceamia. Several MR formulations were designed and in vitro drug release profile was assessed by a dissolution test. For the fur...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Pharmaceutica
سال: 2011
ISSN: 1846-9558,1330-0075
DOI: 10.2478/v10007-011-0016-4